Trial Shows Positive Results for Treatment for Fibromyalgia

On March 7th, in a PR Newswire press release, Innovative Med Concepts announced that the Journal of Pain Research published the results of Phase 2 PRID-201 trial using IMC-1 for the treatment of fibromyalgia (Journal of Pain Research 2017:10 451-460).

The 16 week study was conducted at 12 research centers with 143 fibromyalgia patients.

According to the press release, “The PRID-201 study demonstrated that patients randomized to IMC-1 (celecoxib+famciclovir) experienced a significant decrease in fibromyalgia-related pain vs patients randomized to placebo.  Over 50% of the IMC-1 patients had at least a 30% reduction of pain and 38% of them achieved at least a 50% reduction in pain during the study. Patient global impression of change (PGIC) and the revised disease specific fibromyalgia impact questionnaire (FIQ-R) response rates were also significantly improved.  Additionally, IMC-1 significantly improved self-reported fatigue, as measured by the NIH developed PROMIS fatigue inventory.  Essentially all primary endpoints and most of the secondary endpoints met statistical significance in the PRID201 Trial.”

Phase 2 results show slightly better results than Cymbalta, the most effective of the three FDA-approved fibromyalgia drugs (Lyrica, Cymbalta, and Savella).

Side effects were low, with more patients from the placebo group dropping out of the trial due to adverse reactions than those taking IMC-1.

“The results of this study suggest that IMC-1 is safe and efficacious in the treatment of the symptoms of fibromyalgia.  Based on a novel mechanism of action and the study results showing efficacy on a range of important outcome measures, improved retention rates, decreased adverse event rates, IMC-1 may represent an effective and differentiated treatment for fibromyalgia sufferers.”

The results of this Phase 2 trial are significant in that the FDA has granted IMC-1 fast track status, with IMC planning to start a Phase 3 study with an “improved IMC-1” this year.


En los últimos 100 años, el cannabis ha pasado de ser legal, ilegal, a entrar en una extraña área gris legal en nuestra sociedad. El estigma que rodea al cannabis ha empujado a la gente a creer que es una “droga” que es mala para su salud, cuando en realidad, es una planta que tiene propiedades curativas increíbles.

Cannabis puede ayudar significativamente a las personas que sufren de ansiedad o dolor crónico, e incluso puede matar las células cancerosas. Algunas de las innovaciones más recientes que utilizaron cannabis fueron dos parches para aliviar el dolor creados por Cannabis Science, diseñados para pacientes con fibromialgia y dolor de nervio diabético.

Usos médicos para el cannabis

El cannabis puede y ha sido utilizado durante muchos años para tratar una amplia variedad de enfermedades incluyendo el cáncer. Los cannabinoides se refieren a cualquiera de un grupo de compuestos relacionados que incluyen cannabinol y los constituyentes activos del cannabis.

El consumo de cannabis activa los receptores cannabinoides en el cuerpo, y el propio cuerpo crea compuestos llamados endocannabinoides, que ayudan a producir un ambiente saludable. Los cannabinoides juegan un papel importante en la generación y regeneración del sistema inmunológico, por lo que los cannabinoides reducen las células cancerosas.

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Over the past 100 years, cannabis has gone from being legal, to illegal, to entering a strange legal grey area in our society. The stigma surrounding cannabis has pushed people to believe that it’s a “drug” that’s poor for your health, when in reality, it’s a plant that has incredible healing properties.

Cannabis can significantly help people suffering from anxiety or chronic pain, and can even kill cancer cells. Some of the more recent innovations using cannabis were two pain relieving patches created by Cannabis Science, designed for patients with fibromyalgia and diabetic nerve pain.

Medical Uses for Cannabis

Cannabis can and has been used for many years to treat a wide variety of illnesses including cancer. Cannabinoids refer to any of a group of related compounds that include cannabinol and the active constituents of cannabis.

Consuming cannabis activates cannabinoid receptors in the body, and the body itself creates compounds called endocannabinoids, which help to produce a healthy environment. Cannabinoids play a significant role in immune system generation and re-generation, which is why cannabinoids reduce cancer cells.

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Learning About Fibro Sensitivity and Pain

Tactile Allodynia: Fibro Sensitivity to Touch

Fibromyalgia is well-known for causing widespread pain. This comes in the form of joint, muscle and even nerve pain. What some may not realize though, is these different types of pain have different triggers.

Nerve pain specifically is very different from the other types of pain. It is nerve pain that causes sensitivity to touch, which is known as tactile allodynia.

Tactile allodynia is not quite as common as joint and muscle pain, but it can be very difficult to live with for those who do experience it. As with most of the symptoms of fibromyalgia, this sensitivity to touch can vary in severity from person to person. I personally suffer with it, but not as badly as others I have talked to.

For some, myself included, things like being poked or bumping into a table causes pain, much more than it should. However, for others it is so bad that being lightly touched by another person and even the pressure of their own clothing causes extreme pain.

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Individuals With Low Incomes More Likely to Have Chronic Pain

The prevalence of chronic pain in the U.S. is increasing, and it is the leading cause of disability in the country. According to the National Institutes of Health, it “affects more Americans than diabetes, heart disease, and cancer, combined.” Individuals suffering from chronic pain often have co-morbid symptoms associated with anxiety and depression, and they are often prescribed antidepressants, despite recommendations for treatments to move towards more non-pharmacological approaches. Further, providers often provide opioids for the treatment of chronic pain, an alternative that is considered problematic in the long term.

For this study, the author looked at data collected for a Health and Retirement Study, between 1998 and 2010. The dataset included over 19,000 participants, all aged 51 and older. Individuals with a diagnosis of cancer, or who had been treated for cancer, were excluded from the study.

Results from the longitudinal data point to individuals with lower levels of wealth and education having both more pain and more severe pain. Individuals with the lowest levels of education in the study were 80% more likely to experience chronic pain than those with the most education. In terms of severe pain, those who didn’t finish high school were 370% more likely to experience severe chronic pain than those individuals who attended graduate school. The author also looked at the disability associated with the pain, finding that the same individuals with lower SES were more likely to experience this interference in their day-to-day lives. In addition, the author found that chronic pain not only increased with age, but by time period – i.e., individuals of a certain age group were more likely to report more pain in 2010, than individuals in the same age group 10 years earlier.

“… if you look at the most severe pain, which happens to be the pain most associated with disability and death, then the socioeconomically disadvantaged are much, much more likely to experience it.”

(University of Buffalo News Center)

The study is the first to look at degree of pain in individuals and its associations to SES and mortality. The author concludes with a discussion on the critical importance of investing into understanding chronic pain and developing effective treatments. This is of particular relevance considering recent complicated conversations around the use of opioid treatments and the “punishment” and suffering of chronic pain patients in primary care.

Diagnosing Fibromyalgia May Be Possible Using Noninvasive Eye Examination

Diagnosing fibromyalgia (FM) can be difficult for clinicians because there is no specific diagnostic test and they often rely on a group of symptoms described by their patients.

Now, in a study titled “Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning,” published in the journal PloS One, researchers revealed that a noninvasive eye examination can aid in diagnosing fibromyalgia.

Imaging techniques such as MRI can detect neuronal changes in pain-related brain regions of fibromyalgia patients. However, these types of exams are expensive and not always available in clinical practices. This led researchers to investigate visual loss in fibromyalgia patients, since it is a hallmark of neuronal dysfunction easily detected by routine tests.

The research team examined the visual function of 116 fibromyalgia patients and 144 age-matched healthy controls. Researchers used optical coherence tomography (OCT) to measure a layer of nerve fibers that coats the eye, known as the retinal nerve fiber layer (RNFL).

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Fibromyalgia or Not? 6 Conditions to Know

Fibromyalgia’s hallmark symptoms of fatigue, widespread pain, sleep problems, and difficulty concentrating are not unique. Many other conditions share some of these symptoms.

Fibromyalgia’s many nonspecific symptoms—and the fact that there is no widely accepted diagnostic test for the condition—means that fibromyalgia can be misdiagnosed as something else.

Less well known symptoms of fibromyalgia include irritable bowel syndrome, headaches, menstrual problems, jaw issues, and hypersensitivity to noises and light. The doctor must also take into account the tendency for people living with fibromyalgia to have at least one additional medical condition.

Celiac Disease, Lyme May Be Misdiagnosed

Getting the correct diagnosis is important, so treatment can be tailored to the individual’s situation. Fibromyalgia may be mistaken for one of the following six conditions, among others:

  1. Celiac disease or a gluten sensitivity
  2. Hypothyroidism/Hashimoto’s disease
  3. Lyme disease and other tick-borne diseases
  4. Rheumatoid arthritis
  5. Chronic fatigue syndrome (myalgic encephalomyelitis)
  6. Myofacial pain

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Aprender a aceptar la fibromialgia, primera parte: afrontamiento y carrera

Como la mayoría de las experiencias en la vida, las difíciles o difíciles pueden ser una fuente de aprendizaje y crecimiento personal. Pregunte a la mayoría de los que han tenido una enfermedad crónica durante un largo período de tiempo, y pueden dar fe del hecho de que un proceso de duelo es necesario para aprender a lidiar. El propósito es avanzar de la negación, la lucha contra uno mismo, la depresión y la ira a un estado de aceptación.

El proceso comienza primero con el reconocimiento de que usted, de hecho, tiene fibromialgia. Tuve suerte porque mi médico de atención primaria vio los síntomas y me diagnosticó. Digo “afortunados”, porque la mayoría tiene que pasar por diferentes médicos y sufren durante muchos años antes de recibir un diagnóstico adecuado. Yo estaba tratando con un divorcio en el momento, y recuerda tener fatiga que se quedó conmigo la mayor parte del tiempo. Yo no pensaba nada de eso porque estaba trabajando mucho, y gastando una gran cantidad de energías emocionales. Dormir o descansar un fin de semana entero parecía lógico, sobre todo porque mis niveles de energía volvieron a veces. Después de un accidente automovilístico, mis síntomas se intensificaron y comencé a tener dolores crónicos y dolor pélvico no endometrial, ninguno de los cuales respondió a terapias como calor, meditación, manipulación quiropráctica y masaje.

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Learning to Accept Fibromyalgia, Part One: Coping and Career

Like most experiences in life, the difficult or challenging ones can be a source of learning and personal growth. Ask most who have had a chronic illness for a lengthy amount of time, and they can attest to the fact a grieving process is necessary toward learning to cope. The purpose is to move forward from denial, fighting against oneself, depression and anger to a state of acceptance.

The process begins first with acknowledging that you do, in fact, have fibromyalgia. I was fortunate because my primary care physician saw the symptoms and diagnosed me. I say “fortunate” because most have to go through different doctors and suffer for many years before receiving a proper diagnosis. I was dealing with a divorce at the time, and remember having fatigue that stayed with me most of the time. I thought nothing of it because I was working a lot, and expending a lot of emotional energies. Sleeping or resting an entire weekend seemed logical, especially since my energy levels returned at times. After a car accident, my symptoms escalated and I began having chronic backaches and non-endometrial related pelvic pain, neither of which responded to therapies such as heat, meditation, chiropractic manipulation and massage.

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