Diagnosis and Treatment of Pain in Small Fiber Neuropathy
Small fiber neuropathy frequently is associated with neuropathic pain. The clinical history and physical examination often are sufficient to make the diagnosis of a small fiber neuropathy; however, additional functional and pathological tests may help to confirm the diagnosis. Patients should be carefully screened for reversible causes of small fiber neuropathy. A variety of medications for treatment of pain exist, and there are a number of available consensus guidelines that can aid clinicians in selecting appropriate treatments. For some conditions, such as painful diabetic neuropathy, there are additional treatment guidelines available. However, additional studies specifically targeting the pain in small fiber neuropathy are necessary to support clinical decision making. With the advent of new medications coming to market, further review of the literature will be necessary.