Psoriasis tied to higher risk of serious liver disease
Among people with inflammatory disorders who took systemic therapy – medications that reach the whole body – methotrexate was the most commonly prescribed option.
Overall, 6% of psoriasis patients were prescribed systemic therapy, as were 53% of people with psoriatic arthritis and 61% of people with rheumatoid arthritis.
Independent of risk factors commonly seen in liver disease, such as alcohol use and diabetes, the study found that patients with psoriatic skin or joint disease, particularly patients with more severe skin psoriasis, had an elevated risk for serious liver disease.
Pfizer, which sells a version of methotrexate, has hired Gelfand and another study author as consultants and given them research grants, although the drugmaker wasn’t involved in the design or analysis of the current study. The authors have other financial ties to several other drug companies.