NeuroDerm Reports Promising Phase 2 Results of Continuous Infusion Therapy for Parkinson’s Disease
NeuroDerm’s Phase 2 Parkinson’s disease (PD) trial of ND0612H — a continuous infusion of levodopa and carbidopa delivered by a small belt pump — has met both primary and key secondary endpoints by demonstrating that the treatment effectively reduced “off-time” and increased the number of patients with advanced Parkinson’s who experienced treatment effects in the morning.
In fact, nearly two-thirds of those who responded to the treatment in the trial, referred to as trial 006 by the company, had no off-time at all. Off-time is the time when the effects of Parkinson’s drugs wears off.
“The very prominent responder effect, as well as the significant reductions in OFF-time and troublesome dyskinesia [voluntary movement impairment] observed in trial 006, are extremely encouraging and demonstrate the substantial potential for ND0612 to make a meaningful difference in the lives of patients living with Parkinson’s disease,” NeuroDerm CEO Oded S. Lieberman, PhD, said in a press release.